标题：Split-dose 4-L polyethylene glycol regimen for patients with previous colorectal surgery in bowel preparation before colonoscopy: A randomized, controlled, single-blind study
作者：Liu, Zhu; Li, Yue Yue; Luo, Xue Ting; Guo, Chuan Guo; Zhang, Ming Ming; Li, Zhen; Li, Li Xiang; Zhang, Yan; Li, Yan Qing
作者机构：[Liu, Zhu; Li, Yue Yue; Luo, Xue Ting; Guo, Chuan Guo; Zhang, Ming Ming; Li, Zhen; Li, Li Xiang; Zhang, Yan; Li, Yan Qing] Shandong Univ, Dept Gastroe 更多
通讯作者地址：[Li, YQ]Shandong Univ, Dept Gastroenterol, Lab Translat Gastroenterol, Qilu Hosp, 107 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
来源：JOURNAL OF DIGESTIVE DISEASES
关键词：bowel preparation; colonoscopy; colorectal surgery; polyethylene glycols
摘要：OBJECTIVEWe aimed to investigate the efficacy of a split-dose 4-L polyethylene glycol (PEG) regimen for the quality of bowel preparation in Asian patients with previous colorectal surgery for colorectal cancer (CRC).; METHODSThis was a prospective, single-center, randomized controlled, endoscopist-blinded study. Patients with previous colorectal surgery for CRC were randomly allocated to a routine, morning-only 2-L PEG (2-MO) group or a split-dose 4-L PEG (4-SD) group. The primary outcome was a successful bowel preparation rate. Secondary outcomes were polyp detection rate (PDR), adenoma detection rate (ADR), patient compliance, satisfaction, tolerance, willingness to repeat the preparation and difficulty of the bowel preparation process.; RESULTSIn total, 187 patients were included (93 in the 2-MO group, 94 in the 4-SD group) in this study. The rate of successful bowel preparation in the 4-SD group was higher than in the 2-MO group (89.4% vs 66.7%, P<0.001) in an intention-to-treat analysis according to the Aronchick score. Patients' satisfaction with the bowel preparation process in the 4-SD group was superior to that in the 2-MO group (93.4% vs 82.2%, P= 0.021). No significant differences were detected in PDR, ADR, patient compliance, tolerance, willingness to repeat the preparation or difficulty of the bowel preparation process.; CONCLUSIONSThe 4-SD PEG regimen was superior to a routine, morning-only 2-L PEG preparation for bowel preparation in an Asian population with previous colorectal surgery.