标题：Deformable registration of planning CT and daily cone beam CT for image guided adaptive radiation therapy system
作者：Li, Dengwang ;Wang, Xiuying ;Wang, Hongjun ;Yin, Yong ;Feng, David Dagan
作者机构：[Li, Dengwang ;Wang, Hongjun ] School of Information Science and Engineering, Shandong University, China;[Yin, Yong ] Department of Radiation Oncology 更多
会议名称：18th IFAC World Congress
会议日期：28 August 2011 through 2 September 2011
来源：IFAC Proceedings Volumes (IFAC-PapersOnline)
关键词：Adaptive radiation therapy; Biomedical control system; Cone beam CT; Deformable registration; Image guided radiation therapy; Multi-resolution; Planning CT; Wavelet
摘要：Adequate medical image data analysis could provide improved disease understanding, diagnosis, staging, and measurement of the response to the treatment, especially for radiation therapy system modeling. In image guided radiation therapy systems, it is of great importance to register the planning images with the daily images for adaptive radiation therapy. Because there are various local and global deformations between the image pairs to register, we estimate the deformation in a coarse-to-fine manner using orthogonal wavelet basis. The wavelet coefficients are estimated by minimizing the energy function, where the internal forces are derived from the Navier partial differential equations (PDE) and the external forces are derived from the similarity measure between the registration pairs using normalized mutual information. The experimental results on head-neck and chest cancer studies with both intra- and inter-fraction registration are presented. And we validated the registration method quantitatively using synthetic, pre-defined deformations, and qualitatively using clinical images. The applications of proposed algorithm for image guided adaptive radiation therapy, including 'automatic deformable re-contouring' and 'automatic deformable re-dosing' throughout the course of radiotherapy were also studied. © 2011 IFAC.