标题：Properties and applications of embryonic stem cells
作者：Guo, XX; He, FH
作者机构：[Guo, X] Beijing Institute of Radiation Medicine, Beijing, 100850, China, Department of Life Science, Shandong University, Ji’nan, 250100, China;[ He 更多
通讯作者地址：[He, FH]Beijing Inst Radiat Med, Beijing 100850, Peoples R China.
关键词：embryonic stem cell;differentiation in vitro;cell transplantation therapy;gene targeting
摘要：Mouse embryonic stem (ES) cells are pluripotent cells derived from the early embryo and can be propagated stably in undifferentiated state in vitro. They retain the ability to differentiate into all cell types found in the embryonic and adult body in vivo, and can be induced to differentiate into many cell types under appropriate culture conditions in vitro. Using these properties, people have set up various differentiated systems of many cell types and tissues in vitro. Through analysis of these systems, one can identify novel bioactive factors and reveal mechanisms of cell differentiation and organogenesis. ES cell-derived differentiated cells can also be applied to cell transplantation therapy. In addition, we summarized the features and potential applications of human ES cells.