标题:Structure-Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases
作者:Shi, Riri; Wu, Qiong; Xin, Chenqi; Yu, Houzhi; Lim, Kah-Leong; Li, Xin; Shi, Zhenxiong; Zhang, Cheng-Wu; Qian, Linghui; Li, Lin; H 更多
作者机构:[Shi, Riri; Wu, Qiong; Xin, Chenqi; Zhang, Cheng-Wu; Li, Lin; Huang, Wei] Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab 更多
通讯作者:Zhang, CW;Li, L;Zhang, CW;Li, L
通讯作者地址:[Zhang, CW; Li, L]Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Flexible Elect KLOFE, 30 South Puzhu Rd, Nanjing 211816, 更多
来源:CHEMBIOCHEM
出版年:2019
卷:20
期:12
页码:1487-1497
DOI:10.1002/cbic.201800813
关键词:amines; enzymes; inhibitors; neurotransmitters; oxidation
摘要:Monoamine oxidases (MAOs) are the enzymes that catalyze the oxidation of monoamines, such as dopamine, norepinephrine, and serotonin, which serve as key neurotransmitters in the central nervous system (CNS). MAOs play important roles in maintaining the homeostasis of monoamines, and the aberrant expression or activation of MAOs underlies the pathogenesis of monoamine neurotransmitter disorders, including neuropsychiatric and neurodegenerative diseases. Clearly, detecting and inhibiting the activities of MAOs is of great value for the diagnosis and therapeutics of these diseases. Accordingly, many specific detection probes and inhibitors have been developed and substantially contributed to basic and clinical studies of these diseases. In this review, progress in the detecting and inhibiting of MAOs and their applications in mechanism exploration and treatment of neurotransmitter-related disorders is summarized. Notably, how the detection probes and inhibitors of MAOs were developed has been specifically addressed. It is hoped that this review will benefit the design of more effective and sensitive probes and inhibitors for MAOs, and eventually the treatment of monoamine neurotransmitter disorders.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064003289&doi=10.1002%2fcbic.201800813&partnerID=40&md5=561a1d42d03245b5b82bb84fdf0d04ac
TOP