标题：ADAMTS-12: A Multifaced Metalloproteinase in Arthritis and Inflammation
作者：Wei, Jianlu; Richbourgh, Brendon; Jia, Tanghong; Liu, Chuanju
作者机构：[Wei, Jianlu; Richbourgh, Brendon; Liu, Chuanju] NYU, Med Ctr, Dept Orthopaed Surg, New York, NY 10003 USA.; [Wei, Jianlu; Jia, Tanghong] Shandong U 更多
通讯作者地址：[Jia, TH]NYU, Med Ctr, Dept Orthopaed Surg, 550 1St Ave, New York, NY 10003 USA.
来源：MEDIATORS OF INFLAMMATION
摘要：ADAMTS-12 is a member of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of proteases, which were known to play important roles in various biological and pathological processes, such as development, angiogenesis, inflammation, cancer, arthritis, and atherosclerosis. In this review, we briefly summarize the structural organization of ADAMTS-12; concentrate on the emerging role of ADAMTS-12 in several pathophysiological conditions, including intervertebral disc degeneration, tumorigenesis and angioinhibitory effects, pediatric stroke, gonad differentiation, trophoblast invasion, and genetic linkage to schizophrenia and asthma, with special focus on its role in arthritis and inflammation; and end with the perspective research of ADAMTS-12 and its potential as a promising diagnostic and therapeutic target in various kinds of diseases and conditions.