标题：Small Molecules as PD-1/PD-L1 Pathway Modulators for Cancer Immunotherapy
作者：Jiao, Peifu; Geng, Qiaohong; Jin, Peng; Su, Gaoxing; Teng, Houyun; Dong, Jinlong; Yan, Bing
作者机构：[Jiao, Peifu; Geng, Qiaohong; Jin, Peng; Teng, Houyun] Qilu Normal Univ, Dept Chem, Jinan 250013, Shandong, Peoples R China.; [Yan, Bing] Shandong U 更多
通讯作者：Geng, QH;Yan, B
通讯作者地址：[Geng, QH]Qilu Normal Univ, Dept Chem, Jinan 250013, Shandong, Peoples R China;[Yan, B]Shandong Univ, Sch Environm Sci & Engn, Jinan 250100, Shandong, 更多
来源：CURRENT PHARMACEUTICAL DESIGN
关键词：Immune checkpoint modulators; sulfonamides; thiadiazoles; oxadiazoles;; biphenyl derivatives; molecular docking
摘要：Blockade of PD-1/PD-L1 interactions using PD-1/PD-L1 pathway modulators has shown unprecedented clinical efficacy in various cancer models. Current PD-1/PD-L1 modulators approved by FDA are exclusively dominated by therapeutic antibodies. Nevertheless, therapeutic antibodies also exhibit several disadvantages such as low tumor penetration, difficulty in crossing physiological barriers, lacking oral bioavailability, high manufacturing costs, inaccessible to intracellular targets, immunogenicity, immune-related adverse events (irAEs). Modulation of PD-1/PD-L1 pathway using small molecules may be an alternative approach to mobilize immune system to fight against cancers. In this review, we focus on summarizing the recently disclosed chemical structures and preliminary structure-activity relationships (SARs) of small molecules as PD-1/PD-L1 modulators for cancer immunotherapy.