标题：Interleukin-37 Ameliorates Coxsackievirus B3-induced Viral Myocarditis by Modulating the Th17/Regulatory T cell Immune Response
作者：An, Bang; Liu, Xuefei; Li, Ge; Yuan, Haitao
作者机构：[An, Bang; Liu, Xuefei; Yuan, Haitao] Shandong Univ, Shandong Prov Hosp, Hlth Cardiovasc Dept, 324 JingWu Rd, Jinan 250021, Peoples R China.; [Li, G 更多
会议名称：12th International Symposium for Mechanisms of Vasodilatation - Celebrating the 30th Anniversary of the Announcement of NO as a Vasodilator Molecule
会议日期：NOV 07-09, 2016
来源：JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
关键词：Interleukin-37; myocarditis; inflammation; Th17 cells; regulatory T; cells
摘要：Myocarditis is a heterogeneous group of disorders defined by inflammation of the heart muscle with an excessively activated immune response. Numerous interventions have been investigated for the treatment of myocarditis while success is limited. Interleukin-37 (IL-37), a novel member of the IL-1 cytokine family, is a natural inhibitor of innate immunity associated with autoimmune diseases. However, the modulatory effect of IL-37 in myocarditis is unknown. In this study, we investigated the immunological regulation of IL-37 in the coxsackievirus B3-induced model of murine viral myocarditis. The results show that IL-37 significantly ameliorates the signs of myocarditis with increased survival rate and bodyweight, improved histological changes, reduced activities of MB isoenzyme of creatine kinase and cardiac troponin I, and a suppressed response of Th17 cells and enhanced response of regulatory T cells (Tregs) in the spleen. Moreover, IL-37 down-regulates the expression of Th17-related cytokines IL-6 and IL-17A, while promoting Treg-related cytokine IL-10 levels in the heart. Therefore, IL-37 may exhibit anti-inflammatory activity in the murine model of myocarditis by regulating the balance between Th17 and Treg cells, thereby providing a possible novel therapeutic target in myocarditis.