标题:Pathophysiology of aged lymphatic vessels
作者:Shang, Tongyao; Liang, Jiangjiu; Kapron, Carolyn M.; Liu, Ju
作者机构:[Shang, Tongyao; Liu, Ju] Shandong Univ, Med Res Ctr, Shandong Prov Qianfoshan Hosp, Jinan, Shandong, Peoples R China.; [Liang, Jiangjiu] Shandong F 更多
通讯作者:Liu, J;Liu, J
通讯作者地址:[Liu, J]Shandong Univ, Med Res Ctr, Shandong Prov Qianfoshan Hosp, Jinan, Shandong, Peoples R China;[Liu, J]Shandong First Med Univ, Shandong Prov Qia 更多
来源:AGING-US
出版年:2019
卷:11
期:16
页码:6602-6613
DOI:10.18632/aging.102213
关键词:aging; lymphatic vessels; endothelial cells
摘要:Lymphatic vessels maintain body homeostasis by recirculation of fluid and cells. Cell senescence induces lymphatic dysfunction. Impaired contractile function is caused by low muscle cell investiture and decrease of nitric oxide in aged lymphatic collectors, leading to poor drainage of lymph. Aging-induced loss of endothelial glycocalyx and production of inflammatory cytokines increases permeability of lymphatic vessels. In addition, aging-associated basal activation of mast cells delays immune response. In this review, we summarize the structural and pathological changes of aged lymphatic vessels, and discuss the underlying molecular mechanisms.
收录类别:SCOPUS;SCIE
Scopus被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071788518&doi=10.18632%2faging.102213&partnerID=40&md5=eb7cb7c32fa0a1f1c04df4dec88180d2
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