标题：Long non-coding RNA MAGI2-AS3 inhibits breast cancer cell migration and invasion via sponging microRNA-374a
作者：Du, Shanmei; Hu, Wei; Zhao, Yi; Zhou, Hengzhong; Wen, Wei; Xu, Miao; Zhao, Peiqing; Liu, Kui
作者机构：[Du, Shanmei; Zhou, Hengzhong; Wen, Wei] Zibo Vocat Inst, Zibo 255314, Shandong, Peoples R China.; [Hu, Wei] Zibo Cent Hosp, Dept Breast & Thyroid S 更多
通讯作者：Liu, K;Zhao, PQ
通讯作者地址：[Liu, K]Zibo Cent Hosp, Zibo City Key Lab Individualized Diag & Transform, 54 Gongqingtuan Rd, Zibo 255036, Shandong, Peoples R China;[Zhao, PQ]Zibo C 更多
关键词：lncRNA MAGI2-AS3; breast cancer; migration; invasion; miR-374a; PTEN
摘要：Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts that play important roles in tumorigenesis and tumor progression. Our study aimed to explore the role of lncRNA MAGI2-AS3 in breast cancer metastatic progression. In the present study, our results showed that MAGI2-AS3 can inhibit the migration and invasion of breast cancer cells. In addition, an increase in MAGI2-AS3 can inhibit microRNA-374a (miR-374a) expression in breast cancer cells. Bioinformatic analysis predicted the correlation between MAGI2-AS3 and miR-374a. Phosphatase and tensin homolog (PTEN) was found to be an novel mRNA target of miR-374a. MAGI2-AS3 upregulation inhibited breast cancer metastatic progression by decreasing miR-374a and enhancing PTEN expression. Together, our data revealed that lncRNA MAGI2-AS3 is involved in breast cancer cell progression by regulating the miR-374a-PTEN axis. These findings offer new insight into treatment strategies for breast cancer.