标题：Scaparvin A, A novel caged cis-clerodane with an unprecedented C-6/C-11 bond, and related diterpenoids from the liverwort scapania parva
作者：Guo, D.-X.;Zhu, R.-X.;Wang, X.-N.;Wang, L.-N.;Wang, S.-Q.;Lin, Z.-M.;Lou, H.-X.
作者机构：[Guo, D.-X] Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, C 更多
通讯作者地址：[Lou, HX]Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, 44 W Wenhua Rd, Jinan 250012, Peoples R China.
摘要：Figure Presented. A novel caged cis-clerodane diterpenoid, scaparvin A, possessing an unprecedented C-6/C-11 bond and a ketal ring, as well as four new cis-clerodane derivatives, scaparvins B-E, were isolated from the Chinese liverwort Scapania parva. Their absolute structures were elucidated by analysis of NMR and CD data coupled with electronic circular dichroism (ECD) calculations. It was proposed that an enzymatic intramolecular aldol reaction was the key step in the biogenetic pathway of scaparvin A.