标题：The Cardioprotection of the Insulin-Mediated PI3K/Akt/mTOR Signaling Pathway
作者：Yao, Hong;Han, Xiangyang;Han, Xiuzhen
作者机构：[Yao, H] Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, China;[ Han 更多
通讯作者地址：[Han, XZ]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmacol, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
来源：American journal of cardiovascular drugs: drugs, devices, and other interventions
摘要：Apoptosis occurs frequently in myocardial infarction, oxidative stress injury, and ischemia/reperfusion injury, and plays a pivotal role in the development of heart diseases. Inhibition of apoptosis alone does not necessarily lead to meaningful rescue in terms of either cardiomyocyte survival or function. Activation of the PI3K/Akt signaling pathway induced by insulin not only inhibits cardiomyocyte apoptosis but also substantially preserves and even improves regional and overall cardiac function. Insulin can protect cardiomyocytes from apoptosis by regulating a number of signaling molecules, such as eNOS, FOXOs, Bad, GSK-3 beta, mTOR, NDRG2, and Nrf2, through activating PI3K and Akt. This review focuses on the protective mechanisms and targets of insulin identified in the prevention and treatment of myocardial injury.