标题:Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors
作者:Li, Yingchun; Liu, Yuan; Liu, Jie; Liu, Jiang; Tang, Hui; Cao, Cong; Zhao, Dongsheng; Ding, Yi
作者机构:[Li, Yingchun; Liu, Yuan; Liu, Jie; Liu, Jiang; Tang, Hui] Shihezi Univ, Sch Pharm, Shihezi 832000, Peoples R China.; [Ding, Yi] Tianjin Univ Techno 更多
通讯作者:Li, YC
通讯作者地址:[Li, YC]Shihezi Univ, Sch Pharm, Shihezi 832000, Peoples R China.
来源:SCIENTIFIC REPORTS
出版年:2015
卷:5
DOI:10.1038/srep07699
摘要:Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric conductivity, while electrochemically synthesized MIP thin layer affords selectivity for specific recognition of MNZ molecules. For MNZ determination, the hybrid electrode shows two dynamic linear range of 5x10(-11) to 1x10(-9) mol L-1 and 1x10(-9) to 1.4x10(-6) mol L-1 with a remarkably low detection limit of 1.8 x 10(-11) mol L-1 (S/N=3). In addition, the sensor exhibits high binding affinity and selectivity towards MNZ with excellent reproducibility and stability. Finally, the reliability of MIP-NPGL for MNZ detection is proved in real fish tissue samples, demonstrating the potential for the proposed electrochemical sensors in monitoring drug and biological samples.
收录类别:SCOPUS;SCIE
WOS核心被引频次:36
Scopus被引频次:44
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937702333&doi=10.1038%2fsrep07699&partnerID=40&md5=8e83c8459678e8184e7a7a8e43149663
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