标题: The radiosynthesis of novel PI3K inhibitor , 8-ethoxy-2-(4-[(18) F]fluorophenyl)-3-nitro-2H-chromene ((18) F-EFPNC).
作者: Liu, Jianfeng; Sun, Jinrui; Li, Yuekai; Su, Peng; Hou, Guihua; Han, Jiankui
作者机构:[ Liu, Jianfeng; Liu J] Department of Nuclear Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.;[ Sun, Jinrui; Sun J] Academy of 更多
来源: Journal of labelled compounds & radiopharmaceuticals
出版年:2017
DOI:10.1002/jlcr.3524
摘要: 8-ethoxy-2-(4-[(18) F]fluorophenyl)-3-nitro-2H-chromene((18) F-EFPNC)was preparated through nucleophilic substitution reaction of the precursor 8-ethoxy -2-[(4 -N, N, N-trimethylammonium triflate)phenyl]-3-nitro-2H-chromene and nuclide [(18) F] fluorination. The best radiosynthesis condition was obtained via [(18) F] fluorination substitution reaction between [(18) F] and 18 mg of the precursor in dimethyl sulfoxide(DMSO) at 150 degrees C for 5 min after the radiosynthesis method was optimized.The decay-corrected radiochemical yields(DCRY) of (18) F-EFPNC were 38.5% with total synthesis time of 45 min.The radiochemical purity of (18) F-EFPNC was more than 95% by Thin-layer chromatography(TLC) analysis.The test of (18) F-EFPNC's radiochemical stability showed it was stable at room temperature for up to 2 h.The above results demonstrated that the radiosynthesis method of (18) F-EFPNC was feasible.
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最新影响因子:1.745
资源类型:期刊论文
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