标题：Recent advance of the hepatitis B virus inhibitors: a medicinal chemistry overview
作者：Jia, Haiyong;Rai, Diwakar;Zhan, Peng;Chen, Xuwang;Jiang, Xuemei;Liu, Xinyong
作者机构：[Jia, H] Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), Shandong University, 44 West Culture Road, 250 更多
通讯作者地址：[Liu, XY]Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Key Lab Chem Biol,Minist Educ, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China.
来源：Future medicinal chemistry
摘要：Hepatitis B Virus (HBV) is one of the most prevalent viral infections of human worldwide. The therapies are limited in the clinical context because of negative side effects of interferons and the development of viral resistance to the nucleoside/nucleotide inhibitors. In this review, we summarize the recent advances in design and development of potent anti-HBV inhibitors from natural sources and synthetic compounds, targeting different steps in the life cycle of HBV. We attempt to emphasize the major structural modifications, mechanisms of action and computer-aided docking analysis of novel potent inhibitors that need to be addressed in the future to design potent anti-HBV molecules.