标题:Efficacy and safety of acupuncture as a complementary therapy for sepsis: A protocol of systematic review and meta-analysis
作者:Xian, Jin; Wang, Ling; Zhang, Changyun; Wang, Jian; Zhu, Yushuo; Yu, Huijuan; Zhang, Xin; Tan, Qiwen
作者机构:[Xian, Jin; Zhang, Changyun; Wang, Jian; Zhu, Yushuo] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan, Shandong, Peoples R China.; [Wang, L 更多
通讯作者:Zhang, X;Tan, QW
通讯作者地址:[Zhang, X; Tan, QW]Shandong Univ Tradit Chinese Med, Jinan, Shandong, Peoples R China.
来源:MEDICINE
出版年:2019
卷:98
期:48
DOI:10.1097/MD.0000000000018025
关键词:acupuncture; sepsis; systematic review
摘要:Introduction: Sepsis is a physiological, pathological, and biochemical syndrome caused by infection. Acupuncture may be useful for sepsis. This systematic review aims to assess the efficacy and safety of acupuncture as a complementary therapy for sepsis.; Methods and analysis: We will search PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), Wan Fang Database, Chinese Biomedicine (CBM) database, VIP database, and TCM Literature Analysis and Retrieval Database from inception to October 31, 2019 to identify any eligible study. We include all randomized controlled trials (RCTs) without any limitation of blinding or publication language, exclude cohort studies and case reports. Two reviewers will independently select studies, extract and manage data. The primary outcomes include the mortality at 28 days, acute physiology, and chronic health evaluation II scores. The secondary outcomes include the tumor necrosis factor alpha (TNF-alpha) counts, interleukin 6 (IL-6) counts, interleukin 10 (IL-10) counts, procalcitonin (PCT), lactic acid, the level of T cell subsets (CD3+, CD4+, CD8+, CD4+/CD8+), monocytes of human leukocyte antigen DR (HLA-DR), C-reactive protein (CRP), the numeration of leukocyte, intra-abdominal pressure, and adverse events or reactions. Statistical analyses will be performed using the Review Manager V.5.3 and R packages Metafor. We will use the Cochrane risk of bias tool for randomized trials to assess the risk of bias of included studies.; Ethics and dissemination: This study will not involve personal information. Ethical approval will not be required. We will publish the results in a peer-reviewed journal.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075650967&doi=10.1097%2fMD.0000000000018025&partnerID=40&md5=ea4c054ee3dc1f46e3315ed3fabaacca
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