标题:Design,synthesis and biological activity of cyclohexane-bearing C-glucoside derivatives as SGLT2 inhibitors
作者:Shuo Zhang;Yu-Li Wang;Qun-Chao Wei;Wei-Ren Xu;Li-Da Tang;Gui-Long Zhao;Jian-Wu Wang;
作者机构:[Shuo Zhang;Yu-Li Wang;Qun-Chao Wei;Wei-Ren Xu;Li-Da Tang;Gui-Long Zhao;Jian-Wu Wang]School of Chemistry and Chemical Engineering,Shandong University; 更多
来源:Chinese Chemical Letters
出版年:2013
期:05
页码:429-432
关键词:Synthesis;C-Glucoside;SGLT2 inhibitor;Urinary glucose excretion;Cyclohexane-bearing
摘要:Seven cyclohexane-bearing C-glucoside derivatives(7,9,12,13 and 17-19) were designed and synthesized as SGLT2 inhibitors starting from a potent SGLT2 inhibitor we discovered in earlier work, (lS)-1-deoxy-l-[4-methoxy-3-(trans-n-propylcyclohexyl)methylphenyl]-D-glucose(1).The in vitro and in vivo ...
资源类型:期刊论文
原文链接:http://kns.cnki.net/kns/detail/detail.aspx?FileName=FXKB201305023&DbName=CJFQ2013
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