标题：Hollow fiber membrane-coated functionalized polymeric ionic liquid capsules for direct analysis of estrogens in milk samples
作者：Feng, Juanjuan ;Sun, Min ;Bu, Yanan ;Luo, Chuannan
作者机构：[Feng, Juanjuan ;Sun, Min ;Bu, Yanan ;Luo, Chuannan ] Key Laboratory of Chemical Sensing and Analysis in Universities of Shandong, University of Jinan 更多
来源：Analytical and Bioanalytical Chemistry
摘要：Protein removal process is always time-consuming for the analysis of milk samples. In this work, hollow fiber membrane-coated functionalized polymeric ionic liquid (HF-PIL) capsules were synthesized and used as solid-phase microextraction (SPME) sorbent for direct analysis of estrogens in milk samples. The functionalized PIL monolith sorbent was obtained by copolymerization between 1-(3-aminopropyl)-3-(4-vinylbenzyl)imidazolium 4-styrenesulfonate IL monomer and 1,6-di(3-vinylimidazolium) hexane bishexafluorophosphate IL-crosslinking agent. A group of four capsules were installed as SPME device, to determine four kinds of estrogens (estrone, diethylstilbestrol, hexestrol, and 17α-ethynylestradiol) in milk samples, coupled to high performance liquid chromatography. Extraction and desorption conditions were optimized to get satisfactory extraction efficiency. Good linearity was obtained in the range of 5-200 μg L-1. The limits of detection were 1 μg L-1for diethylstilbestrol and 2 μg L-1for 17α-ethynylestradiol, estrone, and hexestrol. The present method was applied to analyze the model analytes in different milk samples. Relative recoveries were in the range of 85.5-112 %. The HF-PIL SPME capsules showed satisfactory extraction efficiency and high resistance to sample matrix interference.
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