标题：G501C polymorphism of the oxidized LDL receptor gene is associated with albuminuria in Chinese essential hypertension patients
作者：Hou, X. W.; Hu, Z. H.; Cui, Y.; Gao, W.; Sun, S. P.; Wang, N. F.
作者机构：[Hou, X. W.; Gao, W.; Sun, S. P.; Wang, N. F.] Nanjing Med Univ, Hangzhou Municipal Hosp 1, Dept Cardiol, Hangzhou, Zhejiang, Peoples R China.; [Hou 更多
通讯作者地址：[Wang, NF]Nanjing Med Univ, Hangzhou Municipal Hosp 1, Dept Cardiol, Hangzhou, Zhejiang, Peoples R China.
来源：GENETICS AND MOLECULAR RESEARCH
关键词：Albuminuria; Polymorphisms; Essential hypertension; Lectin-like oxidized; low-density lipoprotein receptor 1
摘要：Albuminuria is an independent predictor of renal and cardiovascular complications in hypertensive subjects. We previously showed that lectin-like oxidized low-density lipoprotein receptor 1 (OLR-1) polymorphisms at G501C are associated with susceptibility to essential hypertension and serum C-reactive protein levels. We have now investigated a possible association between OLR-1 polymorphisms at G501C, genotyped by PCR-RFLP, and severity of albuminuria in 307 hypertensive Chinese subjects and 225 age-and gender-matched controls. Urine albumin concentration/urine creatinine concentrations (ACR) were measured to evaluate the severity of albuminuria. Hypertensive subjects had a significantly higher frequency of the CC genotype and the C allele of the OLR-1 polymorphism than controls; this was also true for hypertensive subjects with macroalbuminuria and microalbuminuria compared to those with normoalbuminuria. The mean ACR levels and mean serum C-reactive protein levels in CC carriers were significantly higher than in GG and GC carriers. There was a significant, positive correlation between serum hs-C-reactive protein levels and ACR levels. We conclude that OLR-1 polymorphisms at G501C affect the severity of albuminuria in essential hypertension patients.