标题：Rearranged abietane diterpenoid hydroquinones from aerial parts of Ajuga decumbens Thunb
作者：Wang, Bo;Wang, Xiao-Ning;Shen, Tao;Wang, Shu-Qi;Guo, Dong-Xiao;Lou, Hong-Xiang
作者机构：[Wang, B] Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, Chi 更多
通讯作者地址：[Lou, HX]Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, 44 W Wenhua Rd, Jinan 250012, Peoples R China.
关键词：Ajuga decumbens;Abietane diterpenoids;Ajudecumins A;Cytotoxic
摘要：Four new rearranged abietane diterpenoid hydroquinones, ajudecumins A-D (1-4), together with two known rearranged abietane diterpenoids, three neo-clerodane diterpenoids, four megastigmane derivatives, two flavonoids as well as a bisabolene sesquiterpenoid were isolated from the aerial parts of Ajuga decumbens. Their structures were established on the basis of extensive spectroscopic analysis and the stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis. Among the diterpenoids, compounds 1 and 3 exhibited moderate inhibitory activity on the proliferation of human breast cancer MCF-7 cells. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.