标题：Shape memory materials promoting cell adhesion and tissue invasion towards the applications requiring minimally invasive implantation
作者：Wang, Wei; Zhao, Jia; Li, Chunbo; Pang, Qiying
作者机构：[Wang, Wei] Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Plast & Burn Surg, Jinan, Shandong, Peoples R China.; [Zhao, Jia] Shanghai Jingchen Biotec 更多
通讯作者地址：Li, CB (corresponding author), Fudan Univ, Dept Obstet & Gynecol, Obstet & Gynecol Hosp, Shanghai 200011, Peoples R China.; Pang, QY (corresponding au 更多
来源：JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
关键词：Shape memory scaffold; poly (epsilon-caprolactone); CaP; cellular; adhesion; tissue invasion; minimally invasive implantation
摘要：Minimally invasive implantation of porous implants with large volume forin vivofilling proposes high requirements for material preparation. Porous scaffolds based on shape memory polymer (SMP) possess great potential for being delivered as the compact formviaminimally invasive surgery. Here, poly (epsilon-caprolactone)-dienes (PCL-dienes) and crylic acid (AA) were polymerized and cross-linked to fabricate SMP scaffolds, the porous structure of which was created through particle leaching method. Three scaffolds, PAA-PCL20, PAA-PCL50 and PAA-PCL80 were fabricated with different content of PCL-dienes, possessing similar pore size (350 mu m) and porosity (85%). PAA-PCL50 scaffold had a T(m)of 38 degrees C, exhibiting shape fixing ability at room temperature and shape recovery ability at body temperature. All scaffolds showed limited interaction with cells. The cell adhesion rate of PAA-PCL50 scaffold was 55%, the highest among the three scaffolds. To promote cellular adhesion, PAA-PCL50 scaffold was mineralizedvia in situprecipitation, exhibiting CaP particles on the inner surfaces. The mineralized scaffold still exhibited well-performed deformation and shape memory ability, with higher cell adhesion rate (86%) and proliferation rate.In vivoimplantation result indicated that the mineralized PAA-PCL50 scaffold better supported tissue invasion, holding a great promise to improve neo-tissue formation.