标题:Crosstalk between RNA m6A Modification and Non-coding RNA Contributes to Cancer Growth and Progression
作者:Dai F.; Wu Y.; Lu Y.; An C.; Zheng X.; Dai L.; Guo Y.; Zhang L.;等 更多
作者机构:[Dai, F] Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China, Depar 更多
通讯作者:Gao, W(gaoweisxent@sxent.org)
通讯作者地址:[Gao, W] Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Department of Head & Neck Sur 更多
来源:Molecular Therapy - Nucleic Acids
出版年:2020
卷:22
页码:62-71
DOI:10.1016/j.omtn.2020.08.004
关键词:cancer; circular RNA; long non-coding RNA; microRNA; N6-methyladenosine; non-coding RNA
摘要:N6-methyladenosine (m6A) is the most common RNA modification and has an important role in normal development and tumorigenesis. The abnormal expression of m6A regulators can lead to an imbalance in m6A levels in cancer cells, leading to the dysregulated expression of oncogenes and tumor suppressor genes that may contribute to cancer development, patient response to chemoradiotherapy, and clinical prognosis. Recent studies demonstrate that non-coding RNAs are involved in epigenetic modification of both DNA and RNA in tumor cells, and may also affect the development and progression of cancer by targeting m6A regulators. In this review, we describe the functional crosstalk between m6A and non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, and illustrate their roles in tumor regulation. Finally, we discuss the significance of non-coding RNA and m6A modification in the diagnosis, treatment, and prognosis of cancer patients, as well as potential future research directions. © 2020 The Author(s)As a pivotal member of RNA modification, m6A plays an important role in the initiation and progression of cancer. However, the mechanism between m6A regulators and non-coding RNAs is largely unknown. Gao and colleagues summarize the crosstalk between m6A and non-coding RNAs in cancers and provide potential novel research directions. © 2020 The Author(s)
收录类别:SCOPUS
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090291765&doi=10.1016%2fj.omtn.2020.08.004&partnerID=40&md5=1290fdcf129bff8733faee0d1583b48c
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