标题：Chinese herbal medicine for gout: a review of the clinical evidence and pharmacological mechanisms
作者：Chi, Xiansu; Zhang, Hongxiu; Zhang, Shuo; Ma, Ke
作者机构：[Chi, Xiansu; Zhang, Shuo; Ma, Ke] Shandong Univ Tradit Chinese Med, Shandong Coinnovat Ctr Class TCM Formula, 4655 Univ Rd, Jinan 250355, Shandong, P 更多
通讯作者地址：[Ma, K]Shandong Univ Tradit Chinese Med, Shandong Coinnovat Ctr Class TCM Formula, 4655 Univ Rd, Jinan 250355, Shandong, Peoples R China.
关键词：Gout; Bi pattern; Traditional Chinese medicine; Pharmacological; mechanism
摘要：Gout is a common arthritis condition due to disorders of purine metabolism and decreased uric acid excretion. Although researchers have carried out various studies on this disease, there are no effective drugs for patients with gout. In traditional Chinese medicine (TCM), gout pertains the category of Bi pattern due to qi stagnation in the meridians and collaterals. Chinese herbal medicinals has been employed to treat Bi patterns since the ancient China. In recent decades, classical TCM formulas and agents isolated from some Chinese herbal medicinals have been applied to treat gout and have achieved satisfactory effect. In this review, we focus on recent studies of gout in which TCM formulas were applied to treat animal models or to treat patients, and summarize the mechanism of gout from TCM perspective, the clinical application, pharmacological mechanism and the chemical compounds of TCM formulas in treating gout. In conclusion, through this study, we summarized the application principle of TCM formulas in gout treatment and some key issues of current research, and we hope this study will provide some references for applying TCM formulas to treat gout and will lay a foundation for the development of novel formulas for gout treatments.