标题：Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review)
作者：Deng, Guodong; Liang, Ning; Xie, Jian; Luo, Hui; Qiao, Lili; Zhang, Jingxin; Wang, Dawei; Zhang, Jiandong
作者机构：[Deng, Guodong; Liang, Ning; Xie, Jian; Zhang, Jiandong] Shandong Univ, Qianfoshan Hosp, Dept Radiat Oncol, 16766 Jingshi Rd, Jinan 250014, Shandong, 更多
通讯作者地址：[Zhang, JD]Shandong Univ, Qianfoshan Hosp, Dept Radiat Oncol, 16766 Jingshi Rd, Jinan 250014, Shandong, Peoples R China.
关键词：thoracic malignancy; radiotherapy; radiation pneumonitis; lung fibrosis
摘要：Radiation-induced lung injury (RILI) remains a major obstacle for thoracic radiotherapy for the treatment of lung cancer, esophageal cancer and lymphoma. It is the principal dose-limiting complication, and can markedly impair the therapeutic ratio as well as a patient's quality of life. The current review presents the relevant concepts associated with RILI, including the pathogenic mechanisms and the potential treatment strategies, so as to achieve a general understanding of this issue. RILI comprises an acute radiation pneumonitis phase and subsequent late lung fibrosis. The established assessment criteria are clinical manifestations, imaging changes and the necessity for medical assistance. Risk factors are also considered in order to optimize treatment planning. Due to the underlying molecular mechanisms of RILI, the present review also discusses several targeted pharmacological approaches for its treatment, as well as corticosteroid therapy.