标题：X-ray irradiation accelerates senescence in hippocampal neural stem/progenitor cells via caspase-1 activation
作者：Li, Tao;Li, Lianling;Li, Feng;Liu, Yuguang
作者机构：Shandong Univ, Chinese Minist Publ Hlth, Qilu Hosp, Jinan 250012, Peoples R China;Shandong Univ, Brain Sci Res Inst, Qilu Hosp
来源：Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences
摘要：Despite the effectiveness in controlling the progression of brain tumors, cranial irradiation often causes neuropsychological deficits in cancer survivors. Inflammation is considered a major cause of tissue injury from irradiation. The caspase-1 activation complexes (inflammasomes) can facilitate caspase-1 and IL-1 beta processing, which amplifies the inflammatory response. In the present study we examined whether caspase-1 activation contributes to irradiation-induced damage to neural stem and progenitor cells (NSPCs). We found that X-ray irradiation induced activation of caspase-1 in NSPCs in vitro and in vivo. Next, using a caspase-1 inhibitor (Ac-YVAD-CMK) to block caspase-1 activation in vitro and in vivo, we further demonstrated that X-ray irradiation may inhibit proliferation, induce senescence of NSPCs through caspase-1 activation. Together, our results suggest that caspase-1 activation is involved in irradiation-induced damage to NSPCs. (C) 2014 Elsevier Ireland Ltd. All rights reserved.