标题:X-ray irradiation accelerates senescence in hippocampal neural stem/progenitor cells via caspase-1 activation
作者:Li, Tao;Li, Lianling;Li, Feng;Liu, Yuguang
作者机构:Shandong Univ, Chinese Minist Publ Hlth, Qilu Hosp, Jinan 250012, Peoples R China;Shandong Univ, Brain Sci Res Inst, Qilu Hosp
来源:Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences
出版年:2015
页码:60-65
关键词:Caspase-1;NSPCs;Senescence;Irradiation
摘要:Despite the effectiveness in controlling the progression of brain tumors, cranial irradiation often causes neuropsychological deficits in cancer survivors. Inflammation is considered a major cause of tissue injury from irradiation. The caspase-1 activation complexes (inflammasomes) can facilitate caspase-1 and IL-1 beta processing, which amplifies the inflammatory response. In the present study we examined whether caspase-1 activation contributes to irradiation-induced damage to neural stem and progenitor cells (NSPCs). We found that X-ray irradiation induced activation of caspase-1 in NSPCs in vitro and in vivo. Next, using a caspase-1 inhibitor (Ac-YVAD-CMK) to block caspase-1 activation in vitro and in vivo, we further demonstrated that X-ray irradiation may inhibit proliferation, induce senescence of NSPCs through caspase-1 activation. Together, our results suggest that caspase-1 activation is involved in irradiation-induced damage to NSPCs. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
资源类型:期刊论文
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