作者机构：Qilu Hospital, Shandong University, Jinan, Shandong, China;Qilu Hospital, Shandong University, Jinan, Shandong, China;General Ho
来源：The Journal of arthroplasty
摘要：We appreciate Dr Hamid Namazi\'s insightful ideas regarding the major route that simvastatin could promote osseointegration. Certainly, his ideas have merit, and we would welcome publication of a more complete discussion of the mechanisms for simvastatin-induced osseointegration in total hip arthroplasty. Although there are many studies of effects of statins on osseointegration in total hip arthroplasty, the exact molecular mechanism is unknown. The possibility may include 3 aspects.