标题：DNA repair and synthetic lethality
作者：Guo, Gong-she; Zhang, Feng-mei; Gao, Rui-jie; Delsite, Robert; Feng, Zhi-hui; Powell, Simon N.
作者机构：[Guo, G] School of Public Health, Shandong University, Jinan 250012, China;[ Zhang, F] School of Public Health, Shandong University, Jinan 250012, Chi 更多
通讯作者地址：[Feng, ZH]Shandong Univ, Sch Publ Hlth, Jinan 250012, Peoples R China.
关键词：DNA repair;homologous recombination;synthetic lethality;BRCA;Rad52
摘要：Tumors often have DNA repair defects,suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality.Accumulating data demonstrate that DNA repair-defective tumors,in particular homologous recombination(HR),are highly sensitive to DNA-damaging agents.Thus,HR-defective tumors exhibit potential vulnerability to the synthetic lethality approach,which may lead to new therapeutic strategies.It is well known that poly(adenosine diphosphate(ADP)-ribose)polymerase(PARP)inhibitors show the synthetically lethal effect in tumors defective in BRCAI or BRCA2 genes encoded proteins that are required for efficient HR.In this review,we summarize the strategies of targeting DNA repair pathways and other DNA metabolic functions to cause synthetic lethality in HR-defective tumor cells.