标题:A feasible strategy for focal cerebral ischemia-reperfusion injury: remote ischemic postconditioning
作者:Qiang Liu[1];Shengnian Zhou[1];Yaodong Wang[3];Fang Qi[2];Yuan Song[2];Siwei Long[2]
作者机构:[Qiang Liu;Shengnian Zhou]Department of Neurology,Qilu Hospital of Shandong University.;[]Brain Science Research Institute of Shandong University.;[Fa 更多
通讯作者地址:[Zhou, SN]Shandong Univ, Brain Sci Res Inst, Qilu Hosp, Dept Neurol, 107 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
来源:中国神经再生研究:英文版
出版年:2014
卷:9
期:15
页码:1460-1463
DOI:10.4103/1673-5374.139463
关键词:缺血再灌注损伤;后处理;脑缺血;远程;缺血/再灌注损伤;抗细胞凋亡;保护机制;核因子KB;
摘要:It is difficult to control the degree of ischemic postconditioning in the brain and other ischemia-sensitive organs.Remote ischemic postconditioning could protect some ischemia-sensitive organs through measures on terminal organs.In this study,a focal cerebral ischemia-reperfusion injury model was established using three cycles of remote ischemic postconditioning,each cycle consisted of 10-minute occlusion of the femoral artery and 10-minute opening.The results showed that,remote ischemic postconditioning significantly decreased the percentage of the infarct area and attenuated brain edema.In addition,inflammatory nuclear factor-κB expression was significantly lower,while anti-apoptotic Bcl-2 expression was significantly elevated in the cerebral cortex on the ischemic side.Our findings indicate that remote ischemic postconditioning attenuates focal cerebral ischemia/reperfusion injury,and that the neuroprotective mechanism is mediated by an anti-apoptotic effect and reduction of the inflammatory response.
收录类别:CSCD;SCOPUS;SCIE
WOS核心被引频次:10
Scopus被引频次:12
资源类型:期刊论文
原文链接:http://lib.cqvip.com/qk/88507X/201415/662443444.html
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