标题：Activating transcription factor 3 in cardiovascular diseases: a potential therapeutic target
作者：Zhou, Heng; Li, Ning; Yuan, Yuan; Jin, Ya-Ge; Guo, Haipeng; Deng, Wei; Tang, Qi-Zhu
作者机构：[Zhou, Heng; Li, Ning; Yuan, Yuan; Jin, Ya-Ge; Deng, Wei; Tang, Qi-Zhu] Wuhan Univ, Renmin Hosp, Dept Cardiol, JieFang Rd 238, Wuhan 430060, Hubei, Pe 更多
通讯作者：Tang, QZ;Tang, QZ;Tang, QZ
通讯作者地址：[Tang, QZ]Wuhan Univ, Renmin Hosp, Dept Cardiol, JieFang Rd 238, Wuhan 430060, Hubei, Peoples R China;[Tang, QZ]Wuhan Univ, Cardiovasc Res Inst, Wuhan 更多
来源：BASIC RESEARCH IN CARDIOLOGY
关键词：Activating transcription factor 3; Cardiac hypertrophy; Heart failure;; Atherosclerosis; Cardiovascular diseases
摘要：Cardiovascular diseases (CVDs) are the primary causes of death worldwide. Among the numerous signaling molecules involved in CVDs, transcriptional factors directly influence gene expression and play a critical role in regulating cell function and the development of diseases. Activating transcription factor (ATF) 3 is an adaptive-response gene in the ATF/cAMP responsive element-binding (CREB) protein family of transcription factors that acts as either a repressor or an activator of transcription via the formation of homodimers or heterodimers with other ATF/CREB members. A appropriate ATF3 expression is important for the normal physiology of cells, and dysfunction of ATF3 is associated with various pathophysiological responses such as inflammation, apoptosis, oxidative stress and endoplasmic reticulum stress, and diseases, including CVDs. This review focuses on the role of ATF3 in cardiac hypertrophy, heart failure, atherosclerosis, ischemic heart diseases, hypertension and diabetes mellitus to provide a novel therapeutic target for CVDs.