标题：Who is who in oral cancer?
作者：Zhang, Wei-long; Wang, Sha-sha; Wang, Hao-fan; Tang, Ya-Jie; Tan, Ya-ling; Liang, Xin-hua
作者机构：[Zhang, Wei-long; Wang, Sha-sha; Wang, Hao-fan; Tan, Ya-ling; Liang, Xin-hua] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu, 更多
通讯作者：Tan, YL;Liang, XH;Tang, YJ
通讯作者地址：[Tan, YL; Liang, XH]Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu, Sichuan, Peoples R China;[Tang, YJ]Shandong Univ, Sta 更多
来源：EXPERIMENTAL CELL RESEARCH
关键词：Bacteria; Oral cancer; Carcinogenesis; Porphyromonas gingivalis;; Fusobacterium nucleatum; Treponema denticola; Streptococcus anginosus
摘要：Great attention has been attached to explore the association between oral bacteria and oral cancer. Recently, four common inhabitants of oral cavity, Porphyromonas gingivaiis, Fusobacterium nucleatum, Treponema denticola and Streptococcus anginosus, have been identified as potential etiologic bacterial agents for oral carcinogenesis. They might promote the oncogenesis and progression of oral cancer by induction of chronic inflammation, enhancement of migration and invasiveness, inhibition of cell apoptosis, augment of cell proliferation, suppression of immune system and production of carcinogenic substances. Thus, this review will focus on the possible mechanisms of these oral bacteria contributing to occurrence and development of oral cancer, and the potential clinical implications of utilizing oral bacteria on the diagnosis, prevention and treatment of oral cancer will be discussed.