标题:Organocatalytic Redox Deracemization of Cyclic Benzylic Ethers Enabled by An Acetal Pool Strategy
作者:Wan, Miao; Sun, Shutao; Li, Yangshan; Liu, Lei
作者机构:[Wan, Miao; Sun, Shutao; Li, Yangshan; Liu, Lei] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China.; [Liu, Lei] Shandong Univ, Sch Ch 更多
通讯作者:Liu, Lei
通讯作者地址:[Liu, L]Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China.
来源:ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版年:2017
卷:56
期:18
页码:5116-5120
DOI:10.1002/anie.201701439
关键词:acetals; benzylic ethers; deracemization; redox chemistry; synthetic; methods
摘要:The first redox deracemization of a series of cyclic benzylic ethers, including 6H-benzo[c]chromenes, isochromans, and 1H-isochromenes, is described. An "acetal pool" strategy was adopted to harmonize the complete oxidation of secondary ethers with imidodiphosphoric acid catalyzed asymmetric transfer hydrogenation. The synthetic utility of the process was demonstrated by the effective deracemization of biologically active molecules of interest that are difficult to prepare by other methods.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:8
Scopus被引频次:6
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017354162&doi=10.1002%2fanie.201701439&partnerID=40&md5=98e3d6163d0b82f037ca78d720eb4fa9
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