标题：Comparison of 11C-choline PET/CT and enhanced CT in the evaluation of patients with pulmonary abnormalities and locoregional lymph node involvement in lung cancer
作者机构：[Liu, Q] Cancer Center, Provincial Hospital Affiliated to Shandong University, Shandong University, 324 Jingwu Road, Jinan City, Shandong Province, 25 更多
通讯作者地址：[Liu, Q]Shandong Univ, Prov Hosp, Ctr Canc, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
来源：Clinical lung cancer
关键词：11C-choline PET;CT;Lung cancer;Lymph node metastasis
摘要：Background: This study compares the diagnostic abilities of integrated 11C-choline PET/CT imaging and contrast-enhanced helical CT imaging in pulmonary lesions and locoregional lymph node metastases in patients with lung cancer. Patients and Methods: One hundred eight patients with proven or suspected lung cancer underwent integrated 11C-choline PET/CT and contrast-enhanced CT, followed by surgical resection and nodal staging. Results: The 11C-choline PET/CT and CT diagnoses of pulmonary lesions and locoregional lymph node metastases were compared with pathologic findings, which revealed benign lesions in 26 patients (tuberculoma [8 patients], inflammatory pseudotumor [7 patients], hamartoma [6 patients], sclerosing hemangioma [4 patients], and pulmonary sequestration [1 patient]) and lung cancers in 82 patients (adenocarcinoma [39 patients], squamous cell carcinoma [23 patients], carcinoid [7 patients], small-cell lung cancer [5 patients], adenosquamous carcinoma [5 patients], and large-cell lung cancer [3 patients]). The accuracy, sensitivity, and specificity of 11C-choline PET/CT for diagnosing lung cancer were 82.4%, 85.4%, and 73.1%, respectively, compared with 73.1%, 76.8%, and 61.5%, respectively, for CT. Differences between 11C- choline PET/CT and CT in diagnosing lung cancer were not statistically significant (p =.503,.118, and.375, respectively). We used receiver operating characteristic (ROC) curve for analysis, finding the ROC of standard uptake value (SUV max) for diagnosing lung cancer. The cutoff value of SUV max was 3.54. Preoperative nodal staging was compared with postoperative histopathologic staging. 11C-choline PET/CT correctly staged 80.5% of patients, 12.2% were overstaged, and 7.3% were understaged; for CT these values were 58.5%, 24.4%, and 17.1%, respectively. The accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 11C-choline PET/CT for lymph nodes were 83.8%, 82.4%, 84.1%, 50.3%, and