标题:HLA and MuSK-positive myasthenia gravis: A systemic review and meta-analysis
作者:Hong, Y.; Li, H. -F.; Romi, F.; Skeie, G. O.; Gilhus, N. E.
作者机构:[Hong, Y.; Romi, F.; Gilhus, N. E.] Univ Bergen, Dept Clin Med, Bergen, Norway.; [Li, H. -F.] Shandong Univ, Dept Neurol, Qilu Hosp, Jinan, Shandong 更多
通讯作者:Hong, Y
通讯作者地址:[Hong, Y]Univ Bergen, Dept Clin Med, Bergen, Norway.
来源:ACTA NEUROLOGICA SCANDINAVICA
出版年:2018
卷:138
期:3
页码:219-226
DOI:10.1111/ane.12951
关键词:genetic polymorphism; human leucocyte antigen; meta-analysis;; muscle-specific tyrosine kinase; myasthenia gravis
摘要:ObjectivesMyasthenia gravis (MG) represents a spectrum of clinical subtypes with differences in disease mechanisms and treatment response. MG with muscle-specific tyrosine kinase (MuSK) antibodies accounts for 1%-10% of all MG patients. We conducted a meta-analysis to evaluate the association between HLA genes and MuSK-MG susceptibility.; Subjects and methodsStudies were searched in Pubmed, EMBASE database and other sources between 2001 and 2018. Genotype, allele and haplotype frequencies of HLA loci in MuSK-MG patients and healthy controls were extracted from each included study.; ResultsThe meta-analysis showed that HLA DQB1*05, DRB1*14 and DRB1*16 were strongly associated with an increased risk of MuSK-MG (P<.0001), whereas HLA DQB*03 was less frequent in MuSK patients compared with healthy controls (P<.05). Haplotype analysis showed that these DQB1 and DRB1 alleles were closely linked, forming both risk (DQ5-DR14, DQ5-DR16, P<.0001) and protective (DQ3-DR4, DQ3-DR11, P<.05) haplotypes.; ConclusionThe distinct genetic patterns of MuSK-MG indicate that variation in HLA class II genes plays an important role in the pathogenesis of MuSK-MG patients.
收录类别:SCIE
资源类型:期刊论文
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