标题:Formulation Strategies for Folate-Targeted Liposomes and Their Biomedical Applications
作者:Kumar, Parveen; Huo, Peipei; Liu, Bo
作者机构:[Kumar, Parveen; Huo, Peipei; Liu, Bo] Shandong Univ Technol, Sch Phys & Optoelect Engn, Lab Funct Mol & Mat, Xincun West Rd 266, Zibo 255000, Peoples 更多
通讯作者:Liu, B
通讯作者地址:[Liu, B]Shandong Univ Technol, Sch Phys & Optoelect Engn, Lab Funct Mol & Mat, Xincun West Rd 266, Zibo 255000, Peoples R China.
来源:PHARMACEUTICS
出版年:2019
卷:11
期:8
DOI:10.3390/pharmaceutics11080381
关键词:folic acid; liposomes; folate-targeted; phospholipids; rheumatoid; arthritis
摘要:The folate receptor (FR) is a tumor-associated antigen that can bind with folic acid (FA) and its conjugates with high affinity and ingests the bound molecules inside the cell via the endocytic mechanism. A wide variety of payloads can be delivered to FR-overexpressed cells using folate as the ligand, ranging from small drug molecules to large DNA-containing macromolecules. A broad range of folate attached liposomes have been proven to be highly effective as the targeted delivery system. For the rational design of folate-targeted liposomes, an intense conceptual understanding combining chemical and biomedical points of view is necessary because of the interdisciplinary nature of the field. The fabrication of the folate-conjugated liposomes basically involves the attachment of FA with phospholipids, cholesterol or peptides before liposomal formulation. The present review aims to provide detailed information about the design and fabrication of folate-conjugated liposomes using FA attached uncleavable/cleavable phospholipids, cholesterol or peptides. Advances in the area of folate-targeted liposomes and their biomedical applications have also been discussed.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074079264&doi=10.3390%2fpharmaceutics11080381&partnerID=40&md5=4bf523ec738ee7e8b677fc61d14a210b
TOP