标题：Synthesis of BSA-Coated BiOI@Bi2S3 Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor
作者：Guo, Zhao; Zhu, Shuang; Yong, Yuan; Zhang, Xiao; Dong, Xinghua; Du, Jiangfeng; Xie, Jiani; Wang, Qing; Gu, Zhanjun; Zhao, Yuliang
作者机构：[Guo, Zhao; Zhu, Shuang; Yong, Yuan; Zhang, Xiao; Dong, Xinghua; Du, Jiangfeng; Xie, Jiani; Gu, Zhanjun; Zhao, Yuliang] Chinese Acad Sci, Inst High En 更多
通讯作者：Gu, ZJ;Zhao, YL;Gu, ZJ;Zhao, YL;Zhao, YL
通讯作者地址：[Gu, ZJ; Zhao, YL]Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China;[Gu, ZJ; Z 更多
关键词：bismuth oxyiodide; photodynamic therapy; photothermal therapy;; radiotherapy; semiconductors
摘要：Developing an effective theranostic nanoplatform remains a great challenge for cancer diagnosis and treatment. Here, BiOI@Bi2S3@BSA (bovine serum albumin) semiconductor heterojunction nanoparticles (SHNPs) for triple-combination radio/photodynamic/photothermal cancer therapy and multimodal computed tomography/photoacoustic (CT/PA) bioimaging are reported. On the one hand, SHNPs possess strong X-ray attenuation capability since they contain high-Z elements, and thus they are anticipated to be a very competent candidate as radio-sensitizing materials for radiotherapy enhancement. On the other hand, as a semiconductor, the as-prepared SHNPs offer an extra approach for reactive oxygen species generation based on electron-hole pair under the irradiation of X-ray through the photodynamic therapy process. This X-ray excited photodynamic therapy obviously has better penetration depth in bio-tissue. What's more, the SHNPs also possess well photothermal conversion efficiency for photothermal therapy, because Bi2S3 is a thin band semiconductor with strong near-infrared absorption that can cause local overheat. In vivo tumor ablation studies show that synergistic radio/photodynamic/photothermal therapy achieves more significant therapeutic effect than any single treatment. In addition, with the strong X-ray attenuation and high near-infrared absorption, the as-obtained SHNPs can also be applied as a multimodal contrast agent in CT/PA imaging.