标题:Ansavaricins F-I, new DNA topoisomerase inhibitors produced by Streptomyces sp S012
作者:Zhang, Zhiqiang; Wu, Xingkang; Song, Rentai; Zhang, Juanli; Wang, Haoxin; Zhu, Jing; Lu, Chunhua; Shen, Yuemao
作者机构:[Zhang, Zhiqiang; Wu, Xingkang; Lu, Chunhua; Shen, Yuemao] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 更多
通讯作者:Shen, Yuemao
通讯作者地址:[Shen, YM]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China;[Shen, YM]Shan 更多
来源:RSC ADVANCES
出版年:2017
卷:7
期:24
页码:14857-14867
DOI:10.1039/c7ra00961e
摘要:Ansamycins are a family of macrolactams characterized by an aromatic chromophore with an aliphatic chain (ansa chain) connected back to a nonadjacent position through an amide bond. In this study, four new polyketides of ansamycin class, designated as ansavaricins F-I (1-4), were obtained from the Streptomyces sp. S012 strain. All the compounds were structurally characterized as open-chain streptovaricin derivatives by using NMR and HRESIMS techniques, and showed different degrees of inhibition against human DNA topoisomerases. Ansavaricin H is a promising lead for the development of new inhibitors of human DNA topoisomerases.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014738115&doi=10.1039%2fc7ra00961e&partnerID=40&md5=4004006f06db4dcc15e871a4acbc48c4
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