标题：Ansavaricins F-I, new DNA topoisomerase inhibitors produced by Streptomyces sp S012
作者：Zhang, Zhiqiang; Wu, Xingkang; Song, Rentai; Zhang, Juanli; Wang, Haoxin; Zhu, Jing; Lu, Chunhua; Shen, Yuemao
作者机构：[Zhang, Zhiqiang; Wu, Xingkang; Lu, Chunhua; Shen, Yuemao] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 更多
通讯作者地址：[Shen, YM]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China;[Shen, YM]Shan 更多
摘要：Ansamycins are a family of macrolactams characterized by an aromatic chromophore with an aliphatic chain (ansa chain) connected back to a nonadjacent position through an amide bond. In this study, four new polyketides of ansamycin class, designated as ansavaricins F-I (1-4), were obtained from the Streptomyces sp. S012 strain. All the compounds were structurally characterized as open-chain streptovaricin derivatives by using NMR and HRESIMS techniques, and showed different degrees of inhibition against human DNA topoisomerases. Ansavaricin H is a promising lead for the development of new inhibitors of human DNA topoisomerases.