标题:A bioluminescent strategy for imaging palladium in living cells and animals with chemoselective probes based on luciferin-luciferase system
作者:Ke, Bowen; Chen, Hui; Cui, Yuanyuan; Ma, Lin; Liu, Yuqi; Hu, Xiaotong; Bai, Yu; Du, Lupei; Li, Minyong
作者机构:[Ke, Bowen; Liu, Yuqi; Hu, Xiaotong; Bai, Yu] Sichuan Univ, West China Hosp, West China Brain Res Ctr, Lab Anaesthesiol & Crit Care Med,Translat Neuro 更多
通讯作者:Li, Minyong;Li, MY
通讯作者地址:[Li, MY]Shandong Univ, Sch Pharm, Dept Med Chem, Key Lab Chem Biol,MOE, Jinan 250012, Shandong, Peoples R China.
来源:TALANTA
出版年:2019
卷:194
页码:925-929
DOI:10.1016/j.talanta.2018.11.006
关键词:Bioluminescent probe; Palladium (H); Luciferin-luciferase system; In; vivo imaging
摘要:To develop a strategy for visualizing palladium species in the biological system, several turn-on bioluminescent probes were designed and synthesized by using a Pd-induced reductive reaction herein. Such probes exhibited high sensitivity (detection limit: 0.5 mu M) and excellent selectivity toward Pd2+ in vitro. In particular, probe 2 was identified as a viable molecule with the capability of visualizing the fluctuations of level and distribution of Pd2+ in living cells and animals, which provides a valuable tool for tracing Pd2+ in biological system.
收录类别:EI;SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056450308&doi=10.1016%2fj.talanta.2018.11.006&partnerID=40&md5=06d86ebeadb7a7ec272a22a9842d3e56
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