标题:Catalytic enantioselective cross-dehydrogenative coupling of 3,6-dihydro-2H-pyrans with aldehydes
作者:Xin, Xiaodong; Pan, Xinhui; Meng, Zhilin; Liu, Xigong; Liu, Lei
作者机构:[Xin, Xiaodong; Liu, Lei] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China.; [Pan, Xinhui; Meng, Zhilin; Liu, Xigong; Li 更多
通讯作者:Liu, L;Liu, L;Liu, Lei
通讯作者地址:[Liu, L]Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China;[Liu, L]Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong 更多
来源:ORGANIC CHEMISTRY FRONTIERS
出版年:2019
卷:6
期:9
页码:1448-1452
DOI:10.1039/c9qo00123a
摘要:The existing catalytic asymmetric synthesis of enantiopure alpha-substituted 3,6-dihydro-2H-pyrans and tetrahydropyrans predominantly relies on the oxygen heterocycle construction strategy involving enantioselective cyclization of pre-functionalized olefin substrates. Given the easy availability of the cyclic ether skeleton, we disclosed the first catalytic asymmetric cross-dehydrogenative coupling of 3,6-dihydro-2H-pyrans and aldehydes. The reaction exhibits excellent enantioselectivity, good functional group tolerance, and wide compatibility of diverse 3,6-dihydro-2H-pyran and aldehyde components, thus providing a practical and economical method for enantiopure a-substituted 3,6-dihydro-2H-pyran synthesis.
收录类别:EI;SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064977806&doi=10.1039%2fc9qo00123a&partnerID=40&md5=9168c193e6ee552760a32ecd13c80eb9
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