标题：Tunable morphologies of polymer capsules templated from cuprous oxide particles for control over cell association
作者：Pei, Hongyan; Bai, Yanyan; Guo, Jianman; Gao, Zhiliang; Dai, Qiong; Yu, Qun; Cui, Jiwei
作者机构：[Pei, Hongyan; Bai, Yanyan; Guo, Jianman; Gao, Zhiliang; Dai, Qiong; Yu, Qun; Cui, Jiwei] Shandong Univ, Sch Chem & Chem Engn, Key Lab Colloid & Inter 更多
通讯作者：Yu, Q;Cui, JW
通讯作者地址：[Yu, Q; Cui, JW]Shandong Univ, Sch Chem & Chem Engn, Key Lab Colloid & Interface Chem, Minist Educ, Jinan 250100, Peoples R China.
来源：CHINESE CHEMICAL LETTERS
关键词：Layer-by-layer; Cuprous oxide; Polymer capsules; Cell association;; Polyphenol
摘要：Over the past two decades, layer-by-layer (LbL) assembly of microinanocapsules has been of interest for the investigation of bio-nano interactions to explore bio-applications, such as drug delivery. The choice of an appropriate template that can be easily dissolved under mild conditions is one of the challenges for the assembly of LbL capsules. Herein, we report the engineering of LbL capsules with tunable morphologies using cuprous oxide (Cu2O) particles as templates. Cu2O particles with cubic, tetradecahedral or spherical morphologies were synthesized via hydrothermal processes, which can be dissolved under mild condition (e.g., sodium thiosulfate solution). The influence of capsule morphologies on cell association was investigated, which indicates that LbL capsules with cubic geometry promoted cell association up to 4 and 9-fold than tetradecahedral and spherical capsules, respectively. The reported method provides a new avenue for the assembly of LbL capsules with different morphologies, which has the potential for better understanding of biological interactions of LbL capsules. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.