标题：Internal stimuli-responsive nanocarriers for drug delivery: Design strategies and applications
作者：Liu, Mengrui; Du, Hongliang; Zhang, Wenjia; Zhai, Guangxi
作者机构：[Liu, Mengrui; Du, Hongliang; Zhang, Wenjia; Zhai, Guangxi] Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China.
通讯作者地址：[Zhai, GX]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R China.
来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
关键词：Internal stimuli; Stimuli-responsive; Nanocarriers; Drug delivery;; Targeted drug release
摘要：The design of internal stimuli-responsive nanocarriers has been extensively used for delivery of various active compounds including drugs, peptides and genes. These nanosystems are not only designed for improved solubility, enhanced bioavailability, and prolonged blood circulation time, furthermore, they can be tailored chemically to achieve selective drug release at the desired sites of action, which can enable them to bypass physiological or pathological obstacles and achieve enhanced therapeutic efficacy. This review presents current functional moieties responsive to a variety of internal stimuli, including pH, redox, enzyme, temperature. Their design strategies and biomedical applications are also highlighted in detail. It is expected that this review can provide inspiration and impetus for exploiting more promising internal stimuli-responsive nano-systems for drug delivery. (C) 2016 Elsevier B.V. All rights reserved.