标题：Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects
作者：Shi, Huan; Sun, Meili; Liu, Lin; Wang, Zhehai
作者机构：[Shi, Huan; Liu, Lin; Wang, Zhehai] Shandong Canc Hosp & Inst, Dept Oncol, Jinan 250117, Shandong, Peoples R China.; [Sun, Meili] Shandong Univ, Jin 更多
通讯作者地址：[Liu, L]Shandong Canc Hosp & Inst, Dept Oncol, 440 Jiyan Rd, Jinan 250117, Shandong, Peoples R China.
关键词：Adoptive transfer; Chimeric antigen receptor; Gene transfer; T cells
摘要：Chimeric antigen receptors (CARs) are recombinant receptors that combine the specificity of an antigen-specific antibody with the T-cell's activating functions. Initial clinical trials of genetically engineered CAR T cells have significantly raised the profile of T cell therapy, and great efforts have been made to improve this approach. In this review, we provide a structural overview of the development of CAR technology and highlight areas that require further refinement. We also discuss critical issues related to CAR therapy, including the optimization of CAR T cells, the route of administration, CAR toxicity and the blocking of inhibitory molecules.