标题:Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects
作者:Shi, Huan; Sun, Meili; Liu, Lin; Wang, Zhehai
作者机构:[Shi, Huan; Liu, Lin; Wang, Zhehai] Shandong Canc Hosp & Inst, Dept Oncol, Jinan 250117, Shandong, Peoples R China.; [Sun, Meili] Shandong Univ, Jin 更多
通讯作者:Liu, L
通讯作者地址:[Liu, L]Shandong Canc Hosp & Inst, Dept Oncol, 440 Jiyan Rd, Jinan 250117, Shandong, Peoples R China.
来源:MOLECULAR CANCER
出版年:2014
卷:13
DOI:10.1186/1476-4598-13-219
关键词:Adoptive transfer; Chimeric antigen receptor; Gene transfer; T cells
摘要:Chimeric antigen receptors (CARs) are recombinant receptors that combine the specificity of an antigen-specific antibody with the T-cell's activating functions. Initial clinical trials of genetically engineered CAR T cells have significantly raised the profile of T cell therapy, and great efforts have been made to improve this approach. In this review, we provide a structural overview of the development of CAR technology and highlight areas that require further refinement. We also discuss critical issues related to CAR therapy, including the optimization of CAR T cells, the route of administration, CAR toxicity and the blocking of inhibitory molecules.
收录类别:SCOPUS;SCIE
WOS核心被引频次:15
Scopus被引频次:18
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84908145811&doi=10.1186%2f1476-4598-13-219&partnerID=40&md5=30804032d9498131c5a9ebc1329b5db7
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