标题：Antimicrobial polycyclic polyprenylated acylphoroglucinols from Mesua ferrea flower
作者：Zhang X.-C.; Yang X.-F.; Gu T.-Z.; Cao Y.-F.; Lu C.-H.
作者机构：[Zhang, X.-C] Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong Uni 更多
通讯作者地址：[Lu, C.-H] Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong Univer 更多
关键词：Antibacterial activity; Mesua ferrea; Polycyclic polyprenylated acylphloroglucinols
摘要：Five new polycyclic polyprenylated acylphloroglucinols (PPAPs), named mesuaferroic acids H, I, J, K and L (1–5), together with mesuaferroic acid C (6) and laxifloranone (7), were isolated from the petroleum ether extract of Mesua ferrea flower. Their structures were elucidated by comprehensive spectroscopic techniques including 1D, 2D NMR and HRESIMS. Compounds 1 and 7 exhibited excellent antibacterial activity against Staphylococcus aureus ATCC25923 and a series of multi-drug resistant Gram-positive clinic isolates and the MIC values ranged from 1.0 –16.0 μg/mL, which indicated that the PPAPs might be a new leading structure in antibiotic research. © 2020 Phytochemical Society of Europe