标题：Comparison between two population-based hepatitis B serosurveys with an 8-year interval in Shandong Province, China
作者：Liu, Jiaye; Lv, Jingjing; Yan, Bingyu; Feng, Yi; Song, Lizhi; Xu, Aiqiang; Zhang, Li; Yan, Yongping
作者机构：[Liu, Jiaye; Yan, Yongping] Fourth Mil Med Univ, Sch Publ Hlth, Dept Epidemiol, Xian 710032, Shaanxi, Peoples R China.; [Liu, Jiaye; Lv, Jingjing; Y 更多
通讯作者：Yan, YP;Xu, AQ;Zhang, L;Xu, AQ;Zhang, L
通讯作者地址：[Yan, YP]Fourth Mil Med Univ, Sch Publ Hlth, Dept Epidemiol, Xian 710032, Shaanxi, Peoples R China;[Xu, AQ; Zhang, L]Shandong Univ, Acad Prevent Med, 更多
来源：INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
关键词：Hepatitis B virus; Epidemiology; Cross-sectional study; Vaccine
摘要：Background: Tremendous progress has been made in hepatitis B virus (HBV) prevention and control in the last 30 years in China, but it continues to be a major public health problem. The most recently reported population-based seroepidemiological survey on HBV in Shandong Province in China was published in 2006, and an updated baseline for HBV prevalence was badly needed in the province to identify the change in HBV epidemiology in the last decade.; Methods: Two population-based cross-sectional serosurveys were performed among the population aged 1-59 years in the same sample areas in Shandong Province, China in 2006 and 2014, respectively. Data on demographic characteristics were collected. A blood sample was obtained from each person and was tested for hepatitis B surface antigen (HBsAg), antibody against HBsAg (anti-HBs), and antibody against hepatitis B core antigen (anti-HBc).; Results: Overall, the prevalence rates of HBsAg, anti-HBs, and anti-HBc were 3.39% (95% confidence interval (CI) 2.51-4.26), 44.96% (95% CI 41.34-48.57), and 24.45% (95% CI 22.19-26.71), respectively, among the population aged 1-59 years in the 2006 serovsurvey; the corresponding prevalence rates were 2.49% (95% CI 1.81-3.17), 48.27% (95% CI 45.63-50.92), and 22.56% (95% CI 20.14-24.97), respectively, in 2014. The prevalence rates of HBsAg and anti-HBc were lower in 2014 than in 2006. Conversely, the prevalence of anti-HBs showed an increase. However, none of these differences were statistically significant (all p > 0.05). The prevalence of HBsAg showed an increase among persons aged 20-24 years in 2014 (3.83%) compared with 2006 (2.98%) (t = 0.45, p = 0.67). Among all occupation groups, the prevalence of HBsAg was lower in 2014 than in 2006, while the prevalence of anti-HBc showed moderate increases in students and farmers (all p > 0.05). The prevalence of HBsAg decreased more obviously in urban areas (65.49%) than rural areas (7.07%) from 2006 to 2014.; Conclusions: The epidemiology of HBV infection has changed in Shandong Province, China over the last decade. More attention should be paid to HBV infection among students and farmers. (C) 2017 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.