标题:Advances in the study of structural modifications of multi-target anticancer drug sorafenib
作者:Yao J.-W.; Sun W.; Chen J.; Xu W.-F.
作者机构:[Yao, J.-W] School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China, School of Pharmacy, Yantai University, Yantai 264005, China;[ 更多
通讯作者:Xu, WF(wfxu@yahoo.cn)
通讯作者地址:[Xu, W.-F] School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China;
来源:Yaoxue Xuebao
出版年:2012
卷:47
期:9
页码:1111-1119
关键词:Antitumor agent; Sorafenib analogs; Structural modification; Structure-activity relationship
摘要:Sorafenib, the first oral multikinase inhibitor, can inhibit several kinases involved in tumor proliferation and angiogenesis including Raf, VEGFR, PDGFR, kit and so on. Due to the advantages of multi-mechanisms, broad-spectrum anticancer potency, and well-tolerated results in combination trials, more and more researchers have focused on the optimization of sorafenib in order to develop novel multi-targeted anticancer drugs. The present paper reviews the development of modification of sorafenib in recent years from two aspects: bio-isosterism and scaffold hopping. The structure-activity relationship (SAR) of these compounds is also summarized.
收录类别:SCOPUS;SCOPUS
Scopus被引频次:4
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84869235753&partnerID=40&md5=1eaad28a89242b22bb5b1c6961918d10
TOP