标题:Polycation-telodendrimer nanocomplexes for intracellular protein delivery
作者:Wang, Xu; Shi, Changying; Wang, Lili; Luo, Juntao
作者机构:[Wang, Xu] Shandong Univ, Sch Chem & Chem Engn, Natl Engn Res Ctr Colloidal Mat, 27 Shanda Nanlu, Jinan 250100, Shandong, Peoples R China.; [Shi, Ch 更多
通讯作者:Wang, Xu
通讯作者地址:[Wang, X]Shandong Univ, Sch Chem & Chem Engn, Natl Engn Res Ctr Colloidal Mat, 27 Shanda Nanlu, Jinan 250100, Shandong, Peoples R China;[Luo, JT]SUNY 更多
来源:COLLOIDS AND SURFACES B-BIOINTERFACES
出版年:2018
卷:162
页码:405-414
DOI:10.1016/j.colsurfb.2017.12.021
关键词:Polycation; Telodendrimer; Nanocomplex; Intracellular protein delivery
摘要:Intracellular delivery of protein therapeutics by cationic polymer vehicles is an emerging technique that is, however, encountering poor stability, high cytotoxicity and non-specific cell uptake. Herein, we present a facile strategy to optimize the protein-polycation complexes by encapsulating with linear-dendritic telodendrimers. The telodendrimers with well-defined structures enable the rational design and integration of multiple functionalities for efficient encapsulation of the protein-polycation complexes by multivalent and hybrid supramolecular interactions to produce sub-20 nm nanoparticles. This strategy not only reduces the polycation-associated cytotoxicity and hemolytic activity, but also eliminates the aggregation and non-specific binding of polycations to other biomacromolecules. Moreover, the telodendrimers dissociate readily from the complexes during the cellular uptake process, which restores the capability of polycations for intracellular protein delivery. This strategy overcomes the limitations of polycationic vectors for intracellular delivery of protein therapeutics. (C) 2017 Elsevier B.V. All rights reserved.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:1
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037985408&doi=10.1016%2fj.colsurfb.2017.12.021&partnerID=40&md5=7e5b7a2abc839ba89d63d6ffb1c7e36c
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