标题:ORMDL3 and its implication in inflammatory disorders
作者:Ma, Xiaochun; Long, Feng; Yun, Yan; Dang, Jie; Wei, Shijun; Zhang, Qian; Li, Jinzhang; Zhang, Haizhou; Zhang, Wenlong; Wang, Zhengju 更多
作者机构:[Ma, Xiaochun; Zhang, Qian; Li, Jinzhang; Zhang, Haizhou; Zhang, Wenlong; Wang, Zhengjun; Zou, Chengwei] Shandong Univ, Dept Cardiovasc Surg, Shandong 更多
通讯作者:Wang, ZJ;Zou, CW;Liu, QJ
通讯作者地址:[Wang, ZJ; Zou, CW]Shandong Univ, Dept Cardiovasc Surg, Shandong Prov Hosp, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China;[Liu, QJ]Shandong U 更多
来源:INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
出版年:2018
卷:21
期:6
页码:1154-1162
DOI:10.1111/1756-185X.13324
关键词:apoptosis; autophagy; endoplasmic reticulum stress; inflammation; lipid; metabolism; ORMDL3; polymorphism
摘要:A growing body of evidence has suggested the genetic association of ORMDL3 gene (ORMDL Sphingolipid Biosynthesis Regulator 3) polymorphisms with a diverse set of inflammatory disorders that include bronchial asthma, inflammatory bowel disease, ankylosing spondylitis and atherosclerosis. Gene functional investigations have revealed the particular relevance of ORMDL3 in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of ORMDL3 gene expression in inflammation. This mini-review summarizes the pertinent publications regarding the genetic association studies and mechanistic exploration of ORMDL3 in common inflammatory disorders.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048252429&doi=10.1111%2f1756-185X.13324&partnerID=40&md5=018cb25290c3024c4d2c94abd8cea9fe
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