标题：TANK-binding kinase 1 as a novel therapeutic target for viral diseases
作者：Zhao, Chunyuan; Zhao, Wei
作者机构：[Zhao, Wei] Shandong Univ, Sch Basic Med Sci, Dept Immunol, Jinan, Shandong, Peoples R China.; Shandong Univ, State Key Lab Microbial Technol, Jinan 更多
通讯作者地址：[Zhao, W]Shandong Univ, Sch Basic Med Sci, Dept Immunol, Jinan, Shandong, Peoples R China.
来源：EXPERT OPINION ON THERAPEUTIC TARGETS
关键词：TBK1; innate immune response; TBK1 regulation; virus; viral diseases;; antiviral drugs
摘要：Introduction: TANK-binding kinase 1 (TBK1) is vital for the induction of antiviral innate immune responses. Both RNA and DNA viral infection induces TBK1 activation, triggers phosphorylation of interferon regulatory factor (IRF) 3 and subsequent expression of type I interferons (IFNs; IFN-alpha/beta). Type I IFNs can induce the expression of numerous antiviral genes called interferon-stimulated genes (ISGs) to build a remarkable antiviral state and limit viral replication. Thus, optimal TBK1 activity is crucial for IRF3-induced type I IFNs expression and ISGs-mediated viral elimination.; Areas covered: This review provides an overview of the diverse roles of TBK1 in antiviral innate immune responses, the regulatory mechanisms of TBK1 activity and the implication in antiviral development.; Expert opinion: TBK1 is a key kinase against antiviral infection via inducing type I IFNs expression. Multiple types of post-translational modifications of TBK1 tightly regulate TBK1 activity and subsequent TBK1-dependent antiviral responses. The identified regulators of TBK1 unveil regulatory mechanisms of host antiviral innate immunity and immuno-escape mechanism of virus provide strategies to control viral diseases by modulating TBK1 activity.