标题:TANK-binding kinase 1 as a novel therapeutic target for viral diseases
作者:Zhao, Chunyuan; Zhao, Wei
作者机构:[Zhao, Wei] Shandong Univ, Sch Basic Med Sci, Dept Immunol, Jinan, Shandong, Peoples R China.; Shandong Univ, State Key Lab Microbial Technol, Jinan 更多
通讯作者:Zhao, W
通讯作者地址:[Zhao, W]Shandong Univ, Sch Basic Med Sci, Dept Immunol, Jinan, Shandong, Peoples R China.
来源:EXPERT OPINION ON THERAPEUTIC TARGETS
出版年:2019
卷:23
期:5
页码:437-446
DOI:10.1080/14728222.2019.1601702
关键词:TBK1; innate immune response; TBK1 regulation; virus; viral diseases;; antiviral drugs
摘要:Introduction: TANK-binding kinase 1 (TBK1) is vital for the induction of antiviral innate immune responses. Both RNA and DNA viral infection induces TBK1 activation, triggers phosphorylation of interferon regulatory factor (IRF) 3 and subsequent expression of type I interferons (IFNs; IFN-alpha/beta). Type I IFNs can induce the expression of numerous antiviral genes called interferon-stimulated genes (ISGs) to build a remarkable antiviral state and limit viral replication. Thus, optimal TBK1 activity is crucial for IRF3-induced type I IFNs expression and ISGs-mediated viral elimination.; Areas covered: This review provides an overview of the diverse roles of TBK1 in antiviral innate immune responses, the regulatory mechanisms of TBK1 activity and the implication in antiviral development.; Expert opinion: TBK1 is a key kinase against antiviral infection via inducing type I IFNs expression. Multiple types of post-translational modifications of TBK1 tightly regulate TBK1 activity and subsequent TBK1-dependent antiviral responses. The identified regulators of TBK1 unveil regulatory mechanisms of host antiviral innate immunity and immuno-escape mechanism of virus provide strategies to control viral diseases by modulating TBK1 activity.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064182697&doi=10.1080%2f14728222.2019.1601702&partnerID=40&md5=6483826f7b6853ef62c1f11a6e5e8f0f
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