标题：Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives
作者：Zou, Jinmi; Gao, Ping; Hao, Xia; Xu, Haoran; Zhan, Peng; Liu, Xinyong
作者机构：[Zou, Jinmi; Gao, Ping; Hao, Xia; Xu, Haoran; Zhan, Peng; Liu, Xinyong] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Med Chem,Key Lab Chem Bio 更多
通讯作者地址：[Liu, XY]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Med Chem,Key Lab Chem Biol, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China.
来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
关键词：Ligustrazine derivatives; Pharmacological activities; Drug design;; Antioxidation; Anticardiovascular disease; Anticancer; Neuroprotective;; Antibacterial; Anti-inflammatory
摘要：Ligustrazine is a main active fraction of the traditional medicine known as Ligusticum chuanxiong hort, which has been used as clinical medication for cerebral thrombosis, coronary heart disease and stenocardia recently. The rapid metabolism and short half-life of ligustrazine seriously limits its application in clinical practice. Therefore, derivatives of ligustrazine are designed and synthesized in our and other labs, including piperazine, cinnamic acid, styrene, acylguanidine, amides, curcumin and triterpenes derivatives of ligustrazine. Most of these compounds present better pharmacodynamics activities and more favorable pharmacokinetic properties compared to the parent compound. Besides, some new biological activities of these compounds are discovered. Hence, this review continues the previous review of our group as well as aims to highlight recent prominent advances in this field in the past ten years. (C) 2018 Elsevier Masson SAS. All rights reserved.