标题:Pentraxin-3 as a prognostic marker in patients with small-cell lung cancer
作者:Liu, Chao; Yao, Yao; Wang, Wei
作者机构:[Liu, Chao; Wang, Wei] Shandong Univ, Dept Resp Med, Hosp 2, Jinan 250033, Peoples R China.; [Yao, Yao] Shandong Univ, Sch Med, Dept Histol Embryol, 更多
通讯作者:Wang, W
通讯作者地址:[Wang, W]Shandong Univ, Dept Resp Med, Hosp 2, Jinan 250033, Peoples R China.
来源:MEDICAL ONCOLOGY
出版年:2014
卷:31
期:10
页码:1-6
DOI:10.1007/s12032-014-0207-1
关键词:Small-cell lung cancer; Pentraxin-3; Prognosis; Survival
摘要:The aim of this study was to determine the incidence and role of pentraxin-3 (PTX-3) overexpression as a predictive/prognostic marker in small-cell lung carcinoma (SCLC). We performed a retrospective study on subjects with a biopsy-proven diagnosis of SCLC. A chart review for demographic and clinical data was performed on patients with SCLC diagnosed between 2005 and 2008. PTX-3 overexpression was evaluated using immunohistochemistry performed on archival paraffin-embedded specimens. 125 patients with SCLC were identified (23 females, 102 males; median age 62.91 +/- 8.55 years, range 37-82) all of whom had adequate tissue specimens available for PTX-3 testing. High PTX-3 expression was detected in 25.6 % SCLCs and was significantly associated with male gender and smokers. Moreover, elevated PTX-3 levels were correlated with reduced overall (OS) and disease-free survival, and were an independent negative prognostic factor for OS in SCLC. Our findings suggest that high PTX-3 expression appeared to correlate with aggressive behavior in SCLC, and it may be a useful prognostic marker for SCLC patients and a potential molecular target for SCLC treatment.
收录类别:SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906651169&doi=10.1007%2fs12032-014-0207-1&partnerID=40&md5=6689e27e10c8710e2dd445fe5fb05258
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