标题：The histone acetyltransferase MOF is required for the cellular stress response
作者：Xiaofei Han;Jing He;Xinghong Guo;Abdul Sami Shaikh;Lichao Sun;Shuang Gao;Yiran Liang;Meng Wang;Xiangzhi Li
作者机构：[Yang Yang] Department of Cell and Neurobiology,Shandong University School of Basic Medicine, The Key Laboratory of Experimental Teratology,Ministry o 更多
通讯作者地址：[Li, XZ]Shandong Univ, Sch Basic Med, Minist Educ, Key Lab Expt Teratol, Jinan 250012, Shandong, Peoples R China;[Li, XZ]Shandong Univ, Sch Basic Med, 更多
摘要：When exposing to environmental stress or internal damage,such as genotoxic stress,oxidative stress,and heat stress,cells produce a series of adaptive responses called cellular stress responses. The major proteins involved in cellular stress are heat shock proteins (HSPs). HSPs remain in a low expression level and display a diffused distribution in the nucleoplasm and cytoplasm under basal conditions. In response to various stress conditions,HSPs can be greatly induced and change their subcellular localization to participate in damage response. HSP90,acting as chaperones for protein folding,has anti-apoptotic and pro-metastatic properties. Activation of the genes that encode HSPs is mediated by heat shock transcription factors (HSFs),a master regulator of HSPs in mammalian cells. Under non-stressed conditions,HSF1 interacts with HSP90. Once activated by various stimuli,this interaction becomes dissociated and HSF1 obtains transcription activity,followed by the induction of HSP genes. The stress-induced HSF1 assembly in nuclear stress granules is a significant step in stress response regulation.