标题：Progress on mathematical modeling of controlled drug release using hydrogels as drug carrier
作者：Zhang, Yanyan ;Wang, Fei ;Jia, Yuxi ;Wang, Xiaoxia
作者机构：[Zhang, Yanyan ;Wang, Fei ;Jia, Yuxi ;Wang, Xiaoxia ] Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Ed 更多
来源：Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering
关键词：Drug controlled release; Hydrogels; Mathematical model; Stimuli-responsivity
摘要：Polymeric hydrogels are three-dimensional polymer networks in which individual hydrophilic polymer chains are connected, either by physical association or by chemical bonds. Once stimulated by environmental changes, such as the variation of pH or temperature, hydrogels will respond intelligently and achieve a new equilibrium state in a short time, so they have a wide application in pharmaceutical domain as ideal carriers for drug controlled release. This paper introduced different types of controlled release systems and their major influencing factors, reviewed the development and application of mathematical models describing the drug release processes, comparatively analyzed empirical/semi-empirical models and mechanism models, and presented development trends.